This form of treatment is called autologous hematopoietic stem cell transplantation, or AHSCT. These cells repopulate the immune system, allowing it to reset itself so that the new immune cells no longer attack the central nervous system. Some of the person’s own blood-forming stem cells, which were extracted before treatment, are then infused back into the individual. The experimental treatment involves using a mixture of four chemical agents to remove these immune cells. MS is an autoimmune disease in which a person’s own immune cells attack the central nervous system. NIAIDĪ clinical trial has begun testing an experimental stem cell treatment against the best available biologic therapies for severe forms of relapsing multiple sclerosis (MS). The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, will compare the safety, efficacy and cost-effectiveness of the two therapeutic approaches. In multiple sclerosis, certain kinds of T cells are involved in the immune system’s attack on the central nervous system. Will the stem cells come from you or a donor? Life-threatening complications such as graft-versus-host disease or tumors are less likely when the stem cells are ‘autologous’ meaning they come from your own body.Scanning electron micrograph of a human T cell from the immune system of a healthy donor.Can the staff provide studies published in peer-reviewed medical journals that show evidence that the stem cell types and techniques used have benefit?.What type of cells will be used for the procedure, and why? Stem cells that are specific to certain tissues cannot make cells found in other tissues without manipulation, so it is very unlikely that the same stem cell treatment will work for diseases affecting different tissues and organs within the body.What kind of procedure is proposed? AHSCT (bone marrow transplant) or injection of cells in your body? There is no evidence that injection of cells in the spine or brain has any benefit in MS.Does the center have experience in working with people with MS? What specialists are included on the treatment team?.Is the center and its cell production facility accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) in the U.S.? AHSCT is the only stem cell procedure recommended by the National MS Society and should be performed by accredited centers.Prepare a series of questions for the center and discuss the answers with your MS specialist before moving forward. It is of upmost importance to speak with your MS specialist about where you will have your stem cell treatment and to discuss the type of procedure being performed. d Disease Modifying Therapy Guidance During COVID-19.d Medicines to Prevent and Treat COVID-19.COVID-19 Vaccines for Children and Adolescents with MS and Related Disorders.Timing MS Medications with COVID-19 Vaccines.d COVID-19 Vaccine Guidance for People Living with MS.COVID-19 Information for Healthcare Providers.Resources and Services for Your Patients.Scientific Peer Reviewers & Advisory Committees.Independent Review of Society's Research Programs.Research Studies: Newly Diagnosed with MS.COVID-19 Studies Recruiting People with MS.Families Affected by Multiple Sclerosis.Multiple Sclerosis and the Americans with Disabilities Act (ADA).d Emotional Well-Being and Multiple Sclerosis.d Find Programs & Services in Your Area.Resilience: Addressing the Challenges of MS.Cumbre de Esclerosis Múltiple para Hispanos/Latinx.d aHSCT in MS (Autologous Hematopoietic Stem Cell Transplantation). ![]() d Complementary & Alternative Medicines. ![]()
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